Successful Treatment of Severe Psoriatic Arthritis and Psoriasis with Double Filtration Plasmapheresis

Psoriatic arthritis (PsA) is a chronic, progressive, inflammatory arthropathy associated with psoriasis. Traditional disease modifying anti-rheumatic drugs (DMARDs) have shown inconsistent and unsatisfactory results. Treatment with biological agents has shown different results. Despite the evident efficacy of biologic agents for psoriasis and psoriatic arthritis, there is an increase in psoriasis following biologic agents’ therapies. Psoriasis has no permanent cure and represents a lifelong burden for affected patients. We report herein a successful therapeutic approach for PsA with widespread psoriasis using double filtration plasmapheresis (DFPP) in a 25-year-old female patient. Two months after the first DFPP treatment, a remarkable normalization of the clinical appearance was achieved. During the 3 years follow-up, the patient has had no detectable disease, and a sustained clinical remission has been maintained for 2 years after the interruption of therapy. DFPP therapy led to the complete regression of the severe disease. Therefore, we consider the therapy as promising for treatment of PsA.